6-Methoxy-2-naphthaldehyde → HCID 178440904、化合物

HRID 1594945

反応式

HRID 1594945 の反応式
[Mg:1].C(C1C=C([Br:12])C=CC=1)=C(C)C.CO[C:15]1[CH:24]=[CH:23][C:22]2[C:17](=C[CH:19]=[C:20]([CH:25]=O)[CH:21]=2)[CH:16]=1>C1COCC1>[CH:21]([C:22]1[CH:17]=[C:16]([Mg:1][Br:12])[CH:15]=[CH:24][CH:23]=1)=[C:20]([CH3:25])[CH3:19]

参加物

5

反応物 3

HCID 769916-Methoxy-2-naphthaldehydeHCID 5462224MagnesiumHCID 217068361-Bromo-3-(2-methyl-1-propenyl)benzene

生成物 1

HCID 178440904HCID 178440904、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of Rieke magnesium (0.12 g, 4.74 mmol; commercially available suspension) in dry THF (4.61 mL) was added neat 3-(iso-buten-1-yl)-phenylbromide (1.0 g, 4.74 mmol) at such a rate as to maintain a steady reflux. After the arylbromide was completely added, the reaction was refluxed under nitrogen for 0.5 hours. The solution was allowed to settle for 18 hours and the supernatant was determined to have a 0.56 m titer for active grignard by tritrating a known quantity of 2-methoxynaphthalene-6-carboxaldehyde.

後処理

  1. temperatureto maintain a steady reflux
  2. temperaturethe reaction was refluxed under nitrogen for 0.5 hours

出典と根拠

ORDレコード
ord-465df1866a874a6884707d2ab3413212
出典データセット
uspto-grants-2001_09
特許番号
US06284796B1

関連ノート

読み込み中…