6-Methoxy-2-naphthaldehyde → HCID 178440904、化合物
反応式
[Mg:1].C(C1C=C([Br:12])C=CC=1)=C(C)C.CO[C:15]1[CH:24]=[CH:23][C:22]2[C:17](=C[CH:19]=[C:20]([CH:25]=O)[CH:21]=2)[CH:16]=1>C1COCC1>[CH:21]([C:22]1[CH:17]=[C:16]([Mg:1][Br:12])[CH:15]=[CH:24][CH:23]=1)=[C:20]([CH3:25])[CH3:19]参加物
5
実験手順
To a suspension of Rieke magnesium (0.12 g, 4.74 mmol; commercially available suspension) in dry THF (4.61 mL) was added neat 3-(iso-buten-1-yl)-phenylbromide (1.0 g, 4.74 mmol) at such a rate as to maintain a steady reflux. After the arylbromide was completely added, the reaction was refluxed under nitrogen for 0.5 hours. The solution was allowed to settle for 18 hours and the supernatant was determined to have a 0.56 m titer for active grignard by tritrating a known quantity of 2-methoxynaphthalene-6-carboxaldehyde.
後処理
- temperatureto maintain a steady reflux
- temperaturethe reaction was refluxed under nitrogen for 0.5 hours
出典と根拠
- ORDレコード
- ord-465df1866a874a6884707d2ab3413212
- 出典データセット
- uspto-grants-2001_09
- 特許番号
- US06284796B1
反応ノート
読み込み中…