Water → HCID 10126767、化合物

HRID 1595211ノート

反応式

HRID 1595211 の反応式
[Mn]([O-])(=O)(=O)=[O:2].[K+].[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[O:32][C:31]([CH3:34])([CH3:33])[CH:30]=[CH:29][C:12]2=[C:13]2[C:22]=1[C:21](=[O:23])[C:20]1[CH:19]=[C:18]3[CH:24]=[CH:25][CH:26]=[CH:27][C:17]3=[CH:16][C:15]=1[N:14]2[CH3:28].[OH2:35]>CC(C)=O>[O:35]=[C:29]1[C:12]2=[C:13]3[C:22](=[C:9]([O:8][CH3:7])[CH:10]=[C:11]2[O:32][C:31]([CH3:34])([CH3:33])[CH:30]1[OH:2])[C:21](=[O:23])[C:20]1[CH:19]=[C:18]2[CH:24]=[CH:25][CH:26]=[CH:27][C:17]2=[CH:16][C:15]=1[N:14]3[CH3:28]

参加物

5

反応物 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 9799569HCID 9799569、化合物

生成物 1

HCID 10126767HCID 10126767、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 8.1 g of potassium permanganate diluted in 30 ml of water is slowly added at room temperature to a solution of 3.5 g of the product of Example 2 in 50 ml of acetone. After 2 hours, the solution is concentrated under reduced pressure. The residue is then mixed with silica and then chromatographed on silica gel (dichloromethane/methanol: 98/2), allowing the compound of Example 4, which is present in a small amount, to be isolated from the expected product.

後処理

  1. concentrationthe solution is concentrated under reduced pressure
  2. additionThe residue is then mixed with silica
  3. customchromatographed on silica gel (dichloromethane/methanol: 98/2)

出典と根拠

ORDレコード
ord-09ee8fe9a13c4dd7afeec0bb2349df8b
出典データセット
uspto-grants-2001_09
特許番号
US06288073B1

反応ノート

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