[4-(Morpholin-4-ylmethyl)phenyl]methanamine → Ethyl 5-(4-chlorophenyl)-2-[4-(morpholinomethyl)phenyl]imidazole-4-carboxylate

HRID 1595376ノート

反応式

HRID 1595376 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH2:14][NH2:15])=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23](=O)[C:24](=[N:30]O)[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:19][CH:18]=1>N1C=CC=CC=1>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[NH:15][C:14]([C:11]3[CH:10]=[CH:9][C:8]([CH2:7][N:4]4[CH2:3][CH2:2][O:1][CH2:6][CH2:5]4)=[CH:13][CH:12]=3)=[N:30][C:24]=2[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 2795501[4-(Morpholin-4-ylmethyl)phenyl]methanamineHCID 178472894HCID 178472894、化合物

生成物 1

HCID 178470186Ethyl 5-(4-chlorophenyl)-2-[4-(morpholinomethyl)phenyl]imidazole-4-carboxylate収率 61.5%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

4-(Morpholinomethyl)phenylmethylamine (8 g) and ethyl 3-(4-chlorophenyl) -2-hydroxyimino-3-oxopropionate (8.26 g) were dissolved in pyridine (120 ml) and the mixture was refluxed under heating for 12 hr. The solvent was evaporated under reduced pressure and the obtained residue was subjected to silica gel column chromatography to give the objective ethyl 5-(4-chlorophenyl)-2-[4-(morpholinomethyl)phenyl]imidazole-4-carboxylate (8.46 g), melting point 183-185° C.

後処理

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 12 hr
  3. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-d44807d35368431c8724c55ddde81c27
出典データセット
uspto-grants-2001_09
特許番号
US06288061B1

反応ノート

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