4-Dimethylaminomethylbenzylamine → HCID 178470187、化合物

HRID 1595379

反応式

HRID 1595379 の反応式
[CH3:1][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH2:12])=[CH:7][CH:6]=1)[CH3:3].[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=O)[C:21](=[N:27]O)[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:16][CH:15]=1>N1C=CC=CC=1>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[NH:12][C:11]([C:8]3[CH:9]=[CH:10][C:5]([CH2:4][N:2]([CH3:3])[CH3:1])=[CH:6][CH:7]=3)=[N:27][C:21]=2[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 1937144-DimethylaminomethylbenzylamineHCID 178472894HCID 178472894、化合物

生成物 1

HCID 178470187HCID 178470187、化合物収率 39.7%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

4-(Dimethylaminomethyl)phenylmethylamine (11.7 g) and ethyl 3-(4-chlorophenyl)-2-hydroxyimino-3-oxopropionate (15.1 g) were dissolved in pyridine (220 ml) and the solution was refluxed under heating for 12 hr. The solvent was concentrated under reduced pressure and the obtained residue was subjected to silica gel column chromatography to give the objective ethyl 5-(4-chlorophenyl)-2-[4-(dimethylaminomethyl)phenyl]imidazole-4-carboxylate (9.0 g), melting point 175-176° C.

後処理

  1. temperaturethe solution was refluxed
  2. temperatureunder heating for 12 hr
  3. concentrationThe solvent was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-8990023815794cd68951d6363c30363a
出典データセット
uspto-grants-2001_09
特許番号
US06288061B1

関連ノート

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