Sulfuric Acid → HCID 178489040、化合物

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[C:11]([C:13]([NH:15][C:16]3[S:17][CH:18]=[CH:19][N:20]=3)=[O:14])[N:12]=2)=[CH:4][CH:3]=1.[BH4-].[Na+].S(=O)(=O)(O)O>>[CH2:3]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[C:11]([C:13]([NH:15][C:16]3[S:17][CH:18]=[CH:19][N:20]=3)=[O:14])[N:12]=2)=[CH:4][CH:3]=1)[CH2:4][CH:5]([CH3:8])[CH3:6]

参加物

反応物 3

HCID 1118Sulfuric Acid

HCID 4311764Sodium borohydride

HCID 178489037HCID 178489037、化合物

生成物 1

HCID 178489040HCID 178489040、化合物収率 63.6%

実験手順

2-(4-Aminophenyl)-5-(4-methoxyphenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (0.8 g) obtained in Example 48, sodium borohydride (0.13 g), 2.5N sulfuric acid (0.4 ml) and isopentyl aldehyde (0.3 ml) were treated in the same manner as in Example 72 to give 2-(4-isopentylaminophenyl)-5-(4-methoxyphenyl)-N-(2-thiazolyl)imidazole-4-carboxamide (0.3 g), melting point 235-239° C.

出典と根拠

ORDレコード: ord-3948d3a24bf844ddb04ae417e7c9466d
出典データセット: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06288061B1

反応ノート

読み込み中…