Trifluoroacetic acid → 5-([4-[2-(4-Methanesulfonyloxyphenyl)ethoxy]phenyl]methyl)oxazolidine-2,4-dione

HRID 1595482ノート

反応式

HRID 1595482 の反応式
FC(F)(F)C(O)=O.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:15]2[C:19](=[O:20])[CH:18]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][C:31]4[CH:36]=[CH:35][C:34]([O:37][S:38]([CH3:41])(=[O:40])=[O:39])=[CH:33][CH:32]=4)=[CH:24][CH:23]=3)[O:17][C:16]2=[O:42])C=CC=CC=1>ClCCl>[CH3:41][S:38]([O:37][C:34]1[CH:33]=[CH:32][C:31]([CH2:30][CH2:29][O:28][C:25]2[CH:26]=[CH:27][C:22]([CH2:21][CH:18]3[O:17][C:16](=[O:42])[NH:15][C:19]3=[O:20])=[CH:23][CH:24]=2)=[CH:36][CH:35]=1)(=[O:39])=[O:40]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 217049903-Triphenylmethyl-5-([4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl]methyl)oxazolidine-2,4-dione

生成物 1

HCID 217050105-([4-[2-(4-Methanesulfonyloxyphenyl)ethoxy]phenyl]methyl)oxazolidine-2,4-dione収率 88.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

1 ml trifluoroacetic acid was added to a solution of 0.214 g (0.33 mmole) 3-triphenylmethyl-5-([4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl]methyl)oxazolidine-2,4-dione in 10 ml dichloromethane. After stirring for 45 minutes at room temperature 20 ml more of dichloromethane was added, the reaction mixure was washed twice with water, dried (sodium sulfate) and the solvent was evaporated in vacuo. The crude product was purified by chromatography on silica gel using heptane:ethyl acetate:acetic acid (10:10:1) as eluent to give 0.118 g (yield 88%) of 5-([4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl]methyl)oxazolidine-2,4-dione.

後処理

  1. additionwas added
  2. washthe reaction mixure was washed twice with water
  3. dry with materialdried (sodium sulfate)
  4. customthe solvent was evaporated in vacuo
  5. customThe crude product was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-293df3e401174385b38b570f7984d74c
出典データセット
uspto-grants-2001_09
特許番号
US06288096B1

反応ノート

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