Methanol → 2-(4-Methylsulfanylphenyl)ethanol

HRID 1595532ノート

反応式

HRID 1595532 の反応式
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](O)=[O:11])=[CH:5][CH:4]=1.CO>O1CCCC1>[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][OH:11])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 887MethanolHCID 49839124-(Methylthio)phenylacetic acid

生成物 1

HCID 27600862-(4-Methylsulfanylphenyl)ethanol収率 86.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

5.5 ml 1 M borane-tetrahydrofuiran complex was slowly added to a solution of 1 g (5.5 mmole) 4-(methylmercapto)phenyl acetic acid in 5 ml tetrahydrofuran at −10° C. The reaction mixture was allowed to reach room temperature and the reaction was followed by TLC. After completion 10 ml methanol was added and the solvents were evaporated. Diethyl ether and 2 M sodium hydroxide was added, the phases were separated, the organic phase was dried, filtered and evaporated in vacuo to give 0.8 g (yield 84.4%) of 2-[4-(methylmercapto)phenyl]-1-ethanol.

後処理

  1. customto reach room temperature
  2. customthe solvents were evaporated
  3. additionDiethyl ether and 2 M sodium hydroxide was added
  4. customthe phases were separated
  5. customthe organic phase was dried
  6. filtrationfiltered
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-353e9ef6816b4c148bc6c84bd2d7614d
出典データセット
uspto-grants-2001_09
特許番号
US06288096B1

反応ノート

読み込み中…