Trifluoroacetic acid → HCID 21702192、化合物

HRID 1596539

反応式

HRID 1596539 の反応式
C([O:5][C:6]([C:8]1[C:15]2[C:11]([N:12]([CH2:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[C:29]([Cl:34])[CH:28]=3)[CH:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH:14]=2)=[CH:10][CH:9]=1)=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:6]([C:8]1[C:15]2[C:11]([N:12]([CH2:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[C:29]([Cl:34])[CH:28]=3)[CH:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH:14]=2)=[CH:10][CH:9]=1)([OH:7])=[O:5]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 21702180Benzyl 4-tert-butoxycarbonyl-1-(3,4-dichlorobenzyl)cyclopenta[b]pyrrole-2-carboxylate

生成物 1

HCID 21702192HCID 21702192、化合物収率 98.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Benzyl 4-tert-butoxycarbonyl-1-(3,4dichlorobenzyl)cyclopenta[b]pyrrole-2-carboxylate (0.7 g) was dissolved in methylene chloride (10 mL) and TFA (3 mL) was added. Stirring was continued for 24 hours and the solvents were removed in vacuo to afford a pale oil. The oil slowly solidified on standing to afford the title product (0.61 g, 98%), NMR d(DMSO) 2.40 (4H, m), 3.70 (1H, t), 5.10 (2H, s), 5.40 (2H, AB d), 6.70 (1H, s), 6.90 (1H, d), 7.30 (6H, m), 7.50 (1H, d); M/z (−) 444, 442 (M-H+).

後処理

  1. customthe solvents were removed in vacuo
  2. customto afford a pale oil

出典と根拠

ORDレコード
ord-eddf44201f204b919c44a3656eca1bf0
出典データセット
uspto-grants-2001_09
特許番号
US06291507B1

関連ノート

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