Methylglyoxal → 3-Methoxy-5-methylpyrazine-2-carboxamide

HRID 1596734

反応式

HRID 1596734 の反応式
[NH2:1][CH:2]([C:6]#[N:7])[C:3]([NH2:5])=[O:4].[CH3:8][O-:9].[Na+].[CH3:11][C:12]([CH:14]=O)=O>CO>[CH3:8][O:9][C:6]1[C:2]([C:3]([NH2:5])=[O:4])=[N:1][CH:14]=[C:12]([CH3:11])[N:7]=1

参加物

5

反応物 3

HCID 880MethylglyoxalHCID 983412-Amino-2-cyanoacetamideHCID 10942334Sodium Methoxide

生成物 1

HCID 110627763-Methoxy-5-methylpyrazine-2-carboxamide収率 229%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
20 °C

実験手順

Under argon, 6 g (60.5 mmol) of 2-amino-2-cyanoacetamide was initially charged in 67 g of methanol. 1.67 g (9.3 mmol) of sodium methoxide solution (30%) was added and the mixture was stirred at 20° C. for 2 hours. At 0° C., 11.55 g (64.1 mmol) of methylglyoxal solution (40%) was added and the mixture was stirred at 0° C. for 2 hours. The solution was then cooled to −20° C. The product precipitated out. After filtration and drying, 3.56 g of the title product was obtained. The yield was 39 percent. The melting point of the title product was 170° C. to 172° C. Other data concerning the title product was:

後処理

  1. stirringthe mixture was stirred at 0° C. for 2 hours
  2. temperatureThe solution was then cooled to −20° C
  3. customThe product precipitated out
  4. filtrationAfter filtration
  5. customdrying

出典と根拠

ORDレコード
ord-728b8b619a3443c9bc4b1acb5eb45027
出典データセット
uspto-grants-2001_09
特許番号
US06291674B1

関連ノート

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