Sodium Sulfite → Sodium (4-fluoro-3-phenoxyphenyl)methanesulfonate
反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:4]=1.[S:17]([O-:20])([O-:19])=[O:18].[Na+:21].[Na+]>CO>[F:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:2][S:17]([O-:20])(=[O:19])=[O:18])=[CH:4][C:5]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[Na+:21]参加物
4
実験手順
A mixture of α-bromo-4-fluoro-3-phenoxytoluene (4.86 g, 17.3 mmol) and sodium sulfite (2.39 g, 19 mmol) in 50% aqueous methanol (20 mL) is heated at reflux for 5 hours and cooled to room temperature. The resultant colorless solid is collected by filtration and washed with chilled 50% aqueous methanol and methanol to obtain 3.4 g of sodium (4-fluoro-3-phenoxyphenyl)methanesulfonate. Another 1.8 g of product is recovered from the mother liquors.