Water → HCID 21698925、化合物

HRID 1597185ノート

反応式

HRID 1597185 の反応式
[F:1][C:2]1[C:12]([N:13]2[C:21](=[O:22])[C:20]3[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=3[C:14]2=[O:23])=[C:11]([N+:24]([O-])=O)[C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=1.O>C(O)(=O)C.[Fe]>[NH2:24][C:11]1[C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=[C:2]([F:1])[C:12]=1[N:13]1[C:21](=[O:22])[C:20]2[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=2[C:14]1=[O:23]

参加物

5

反応物 2

HCID 962WaterHCID 21698918HCID 21698918、化合物

生成物 1

HCID 21698925HCID 21698925、化合物収率 104.7%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 176Acetic Acid溶媒

実験手順

2-[7-Fluoro-5-nitro-2H-1,4-benzoxazine-3(4H)-on-6-yl]-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione (1.25 g) was dissolved in acetic acid (13 ml) and iron powder (0.77 g) was added with stirring. Solution was stirred at ambient temperature for 12 hr and water was added. Product was extracted with ethyl acetate to afford the title compound (1.2 g).

後処理

  1. stirringSolution was stirred at ambient temperature for 12 hr
  2. extractionProduct was extracted with ethyl acetate

出典と根拠

ORDレコード
ord-8fa45bbf7e774577af0afe6034ac7418
出典データセット
uspto-grants-2001_09
特許番号
US06294503B1

反応ノート

読み込み中…