7-Benzyloxy4-(2-methoxyethylsulphanyl)quinazoline → 7-Hydroxy-4-(2-methoxyethylsulphanyl)quinazoline
反応式
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([S:19][CH2:20][CH2:21][O:22][CH3:23])=[N:14][CH:15]=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[OH:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([S:19][CH2:20][CH2:21][O:22][CH3:23])=[N:14][CH:15]=[N:16]2)=[CH:11][CH:10]=1参加物
3
実験手順
A solution of 7-benzyloxy-4-(2-methoxyethylsulphanyl)quinazoline (8 g, 24.5 mmol) in TFA (80 ml) was refluxed for 5 hours. After cooling and removal of the volatiles by evaporation, the residue was triturated with water, collected by filtration, washed with water and then ethyl acetate. The residue was resuspended in methylene chloride, filtered, washed with petroleum ether and dried under vacuum to give 7-hydroxy-4-(2-methoxyethylsulphanyl)quinazoline (5.8 g, quant.).
後処理
- temperature