1-(1-Benzyloxycarbonyl-4-piperidinylmethyl)-4-(t-butoxycarbonylamino)piperidine → 4-(t-Butoxycarbonylamino)-1-(4-piperidinylmethyl)piperidine

HRID 1597309ノート

反応式

HRID 1597309 の反応式
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][N:18]2[CH2:23][CH2:22][CH:21]([NH:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:20][CH2:19]2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[C:28]([O:27][C:25]([NH:24][CH:21]1[CH2:20][CH2:19][N:18]([CH2:17][CH:14]2[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]2)[CH2:23][CH2:22]1)=[O:26])([CH3:31])([CH3:29])[CH3:30]

参加物

4

反応物 1

HCID 129861531-(1-Benzyloxycarbonyl-4-piperidinylmethyl)-4-(t-butoxycarbonylamino)piperidine

生成物 1

HCID 129861544-(t-Butoxycarbonylamino)-1-(4-piperidinylmethyl)piperidine収率 107%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 1-(1-benzyloxycarbonyl-4-piperidinylmethyl)-4-(t-butoxycarbonylamino)piperidine (5.6 g) in ethanol (100 ml) is added 5% palladium-on-carbon (0.6 g), and the mixture is hydrogenated at 30° C. under atmospheric pressure. After a theoretical amount of hydrogen is consumed, the catalyst is removed by filtration, and the ethanol in the filtrate is evaporated under reduced pressure to give crude 4-(t-butoxycarbonylamino)-1-(4-piperidinylmethyl)piperidine (4.13 g).

後処理

  1. customis hydrogenated at 30° C. under atmospheric pressure
  2. customAfter a theoretical amount of hydrogen is consumed
  3. customthe catalyst is removed by filtration
  4. customthe ethanol in the filtrate is evaporated under reduced pressure

出典と根拠

ORDレコード
ord-87d64ad26c6447028e728b7a35ab379e
出典データセット
uspto-grants-2001_09
特許番号
US06294555B1

反応ノート

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