Ethyl bromoacetate → 1-{3-[(4'-Fluoro[1,1'-biphenyl]-4-yl)sulfonyl]-2-hydroxypropyl}-4,4-dimethyl-2,6-piperidinedione

HRID 1597425

反応式

HRID 1597425 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:18][C:19]1([CH3:27])[CH2:25][C:24](=[O:26])[NH:23][C:21](=[O:22])[CH2:20]1.Br[CH2:29][C:30](OCC)=[O:31]>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:8]2[CH:7]=[CH:6][C:5]([S:2]([CH2:1][CH:30]([OH:31])[CH2:29][N:23]3[C:24](=[O:26])[CH2:25][C:19]([CH3:27])([CH3:18])[CH2:20][C:21]3=[O:22])(=[O:4])=[O:3])=[CH:10][CH:9]=2)=[CH:12][CH:13]=1

参加物

4

反応物 3

HCID 7748Ethyl bromoacetateHCID 142924,4-Dimethylpiperidine-2,6-dioneHCID 160868644-(4'-Fluorophenyl)-phenyl methyl sulfone

生成物 1

HCID 217000651-{3-[(4'-Fluoro[1,1'-biphenyl]-4-yl)sulfonyl]-2-hydroxypropyl}-4,4-dimethyl-2,6-piperidinedione

実験手順

Reaction of 4-(4′-fluorophenyl)-phenyl methyl sulfone with ethyl 3,3-dimethylglutarimideacetate (prepared from 3,3-Dimethylglutarimide and ethyl bromoacetate (as in Example 120A) following the procedures of Example 126A, followed by reduction as described in Example 126B afforded the two title products which were chromatographically separated to give the desired products.

後処理

  1. customafforded the two title products which
  2. customwere chromatographically separated

出典と根拠

ORDレコード
ord-143eb7e78acf4da381a50e842631a733
出典データセット
uspto-grants-2001_09
特許番号
US06294573B1

関連ノート

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