Hydrochloric Acid → Ethanol ammonium hydroxide water
反応式
[N:1]1C=CC(CC[CH2:9][C:10](N(CC(O)=O)C)=[O:11])=CC=1.[CH2:18]([O:20][C:21](=[O:36])[CH2:22][C@@H](CCC1C2C(=CC=CC=2)NC=1)[NH2:24])[CH3:19].[OH-:37].[Na+].Cl>CCO>[CH3:9][CH2:10][OH:11].[OH2:20].[NH4+:1].[OH-:37].[CH3:19][CH2:18][O:20][C:21]([CH3:22])=[O:36].[CH3:9][CH2:10][OH:11].[OH2:11].[NH4+:24].[OH-:11]参加物
6
実験手順
Ester 6-3 (400 mg, 0.84 mmol) was dissolved in 4 mL EtOH, then 1 N NaOH (1.7 mL, 1.7 mmol) was added. After 90 min the reaction was neutralized with 1 N HCl (1.7 mL, 1.7 mmol) and concentrated to an oil. Flash chromatography (silica, 50:1:1 EtOH/H2O/NH4OH, then again with 12:10:1:1 EtOAc/EtOH/H2O/NH4OH) provided 6-4.
後処理
- concentrationconcentrated to an oil
出典と根拠
- ORDレコード
- ord-8d74f4301b9e4ce09acd05ced3b8cd8c
- 出典データセット
- uspto-grants-2001_09
- 特許番号
- US06294549B1
反応ノート
読み込み中…