Tetrahydrofuran → 6-chloro-5-nitro-1H-indole

HRID 1598004ノート

反応式

HRID 1598004 の反応式
C1COCC1.ClC1C=C2C(C=CN2)=CC=1F.[Cl:17][C:18]1[CH:26]=[C:25]2[C:21]([CH2:22][CH2:23][NH:24]2)=[CH:20][C:19]=1[N+:27]([O-:29])=[O:28].B.N1C=CC=CC=1>>[Cl:17][C:18]1[CH:26]=[C:25]2[C:21]([CH:22]=[CH:23][NH:24]2)=[CH:20][C:19]=1[N+:27]([O-:29])=[O:28]

参加物

5

反応物 4

HCID 8028TetrahydrofuranHCID 2723995Borane;pyridineHCID 27736486-Chloro-5-fluoro-1H-indoleHCID 189329026-chloro-5-nitro-2,3-dihydro-1H-indole

生成物 1

HCID 189328576-chloro-5-nitro-1H-indole

実験手順

This material was produced from 6-chloro-5-nitro-oxindole (1 eq) and BH3 /THF (6 mol eq.) utilizing a method analogous to that described for 6-chloro-5-fluoro-indole (Preparation 29) in 99% yield (contaminated with some 6-chloro-5-nitro-indoline) and used directly in the subsequent borane/pyridine reduction.

出典と根拠

ORDレコード
ord-b0500a985ce943bc94aa95966f762a00
出典データセット
uspto-grants-1998_04
特許番号
US05736534

反応ノート

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