2-Amino-1-phenylpropan-1-ol hydrochloride → (1S,2R)-(+)-Norephedrine

HRID 1598295

反応式

HRID 1598295 の反応式
[CH3:1][CH:2]([NH2:11])[CH:3]([OH:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.Cl.[OH-].[Na+]>O>[CH3:1][CH:2]([NH2:11])[CH:3]([OH:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 90652-Amino-1-phenylpropan-1-ol hydrochlorideHCID 14798Sodium Hydroxide

生成物 1

HCID 4786(1S,2R)-(+)-Norephedrine

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Phenylpropanolamine hydrochloride was dissolved in the water and to this solution there was added, rapidly with stirring, 20 gm of sodium hydroxide dissolved in 100 ml of water. The mixture was allowed to stand at 10° C. overnight. Crystals of the free base were filtered, washed with water and dried in vacuum over calcium chloride. This process yielded 59 gm of free base phenylpropanolamine.

後処理

  1. additionwas added
  2. filtrationCrystals of the free base were filtered
  3. washwashed with water
  4. dry with materialdried in vacuum over calcium chloride

出典と根拠

ORDレコード
ord-8f8fd49571a64745887468f718f48809
出典データセット
uspto-grants-1998_04
特許番号
US05736573

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