Trifluoroacetic acid → 4-(Carboxymethyloxy)-4'-cyano-biphenyl

HRID 1598395ノート

反応式

HRID 1598395 の反応式
C([O:5][C:6]([CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[C:6]([CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=2)=[CH:14][CH:15]=1)([OH:7])=[O:5]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 640094Tert-butyl [(4'-cyanobiphenyl-4-yl)oxy]acetate

生成物 1

HCID 432431004-(Carboxymethyloxy)-4'-cyano-biphenyl

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

32.9 g of 4-(tert.butyloxycarbonylmethyloxy)-4'-cyano-biphenyl dissolved in 250 ml of methylene chloride is mixed slowly with 137 ml of trifluoroacetic acid. After stirring for 3 hours, the reaction mixture is evaporated to dryness and the solid residue is triturated with water.

後処理

  1. customthe reaction mixture is evaporated to dryness
  2. customthe solid residue is triturated with water

出典と根拠

ORDレコード
ord-1eb3d61987aa4b5a89fe81711f8f2f14
出典データセット
uspto-grants-1998_04
特許番号
US05736559

反応ノート

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