Tetrahydrofuran → N-propyl-2,3-dihydro-1H-inden-2-amine

HRID 1598564ノート

反応式

HRID 1598564 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].C([CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]1N)(=O)CC.[Cl-].[NH4+:22].O1C[CH2:26][CH2:25][CH2:24]1>>[CH2:24]([NH:22][CH:11]1[CH2:12][C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:19]1)[CH2:25][CH3:26]

参加物

5

反応物 4

HCID 8028Tetrahydrofuran2 回HCID 25517Ammonium ChlorideHCID 21226445Aluminium lithium hydride2 回HCID 543218082-Propionyl aminoindane

生成物 1

HCID 17221237N-propyl-2,3-dihydro-1H-inden-2-amine

実験手順

In 100 ml of tetrahydrofuran was suspended 5.7 g of lithium aluminum hydride, and to the suspension was added dropwise 18.9 g of 2-propionyl aminoindane dissolved in 150 ml of tetrahydrofuran. The mixture was refluxed under heating for 2 hours. After cooling, excessive lithium aluminum hydride was treated with a saturated ammonium chloride aqueous solution, and insolubles were removed by filtration. The filtrate was condensed, and chloroform was added to the residue. After the mixture was washed with 10 water and dried, the solvent was removed to obtain 17.5 g of 2-propylaminoindane.

後処理

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating for 2 hours
  3. temperatureAfter cooling
  4. customwere removed by filtration
  5. customcondensed, and chloroform
  6. additionwas added to the residue
  7. washAfter the mixture was washed with 10 water
  8. customdried
  9. customthe solvent was removed

出典と根拠

ORDレコード
ord-968c44bf8df84e558d1424ad845337e4
出典データセット
uspto-grants-1998_04
特許番号
US05739132

反応ノート

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