Hydrazine hydrate (1:1) → HCID 178418252、化合物
反応式
[Br:1][C:2]1[CH:11]=[C:10]([CH2:12][CH3:13])[CH:9]=[C:8]2[C:3]=1[C:4]([OH:22])=[C:5]([C:18](OC)=[O:19])[C:6]([C:14](OC)=[O:15])=[N:7]2.O.[NH2:24][NH2:25]>C(O)C>[Br:1][C:2]1[C:3]2[C:4]([OH:22])=[C:5]3[C:18](=[O:19])[NH:25][NH:24][C:14](=[O:15])[C:6]3=[N:7][C:8]=2[CH:9]=[C:10]([CH2:12][CH3:13])[CH:11]=1参加物
4
実験手順
To a mixture of dimethyl 5-bromo-7-ethyl-4-hydroxyquinoline-2,3-dicarboxylate (1.0 g, 2.7 mM,) in ethanol (25 mL) was added hydrazine hydrate (0.68 g, 14 mM). The resulting mixture was concentrated at 30° C. using a rotary evaporator and the residue was diluted with another portion of ethanol (25 mL) and similarly concentrated at 30° C. The residue was suspended in ethanol and filtered to separate the title compound (0.82 g, 82%) as a light yellow solid. Recrystallization of a portion of this material from dimethylsulfoxide/ethanol provided an analytical sample of the title compound as a light yellow crystalline solid, mp 335°-340° C. (dec).