Sulfuric Acid → 4-Chloro-2-fluoro-5-sulfamoylbenzoic acid

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](Cl)(Cl)Cl)=[C:4]([F:12])[CH:3]=1.[OH:13][S:14](Cl)(=O)=[O:15].S(=O)(=O)(O)[OH:19].[OH-:23].[NH4+:24]>>[Cl:1][C:2]1[C:7]([S:14](=[O:15])(=[O:13])[NH2:24])=[CH:6][C:5]([C:8]([OH:19])=[O:23])=[C:4]([F:12])[CH:3]=1

参加物

反応物 4

HCID 1118Sulfuric Acid

HCID 14923Ammonium Hydroxide

HCID 24638Chlorosulfonic acid

HCID 189316154-Chloro-2-fluoro-1-(trichloromethyl)benzene

生成物 1

HCID 124625724-Chloro-2-fluoro-5-sulfamoylbenzoic acid

実験手順

4-chloro-2-fluoro-benzotrichloride (III) obtained in step (A) is chlorosulfonylated by treatment with sulfuric chlorohydrin in the presence of sulfuric acid and the resulting product is ammonolyzed by treatment with ammonium hydroxide to give 4-chloro-2-fluoro-5-sulfamoyl-benzoic acid (IV);

出典と根拠

ORDレコード: ord-0e15f147aa2947928872a1644447127e
出典データセット: uspto-grants-1998_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05739361

反応ノート

読み込み中…