HCID 67661107、化合物 → (3aRS,4RS,6SR,7aSR)-6-hydroxymethyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol
反応式
C([N:8]1[CH2:16][CH:15]2[CH:10]([CH2:11][CH:12]([CH2:26][OH:27])[CH2:13][C:14]2([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH3:25])[OH:17])[CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[OH:27][CH2:26][CH:12]1[CH2:11][CH:10]2[CH:15]([CH2:16][NH:8][CH2:9]2)[C:14]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH3:25])([OH:17])[CH2:13]1参加物
4
実験手順
A suspension of 3.1 g of (3aRS,4RS,6SR,7aSR)-2-benzyl-6-hydroxymethyl-4-(2-methoxyphenyl) perhydroisoindol-4-ol and 0.5 g of 20% palladium hydroxide on carbon black in 75 cm3 of ethanol is hydrogenated under atmospheric pressure at 60° C. for 3 hours. The reaction mixture is subsequently filtered and concentrated to dryness under reduced pressure (2.7 kPa). 3.0 g of (3aRS,4RS,6SR,7aSR)-6-hydroxymethyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol are obtained in the form of a thick white foam.