2-Chlor-5-nitro-benzolsulfonylfluorid → 5-Amino-2-chlorobenzene-1-sulfonyl fluoride

HRID 1599206ノート

反応式

HRID 1599206 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[S:11]([F:14])(=[O:13])=[O:12]>C(O)(=O)C.[Fe]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[S:11]([F:14])(=[O:12])=[O:13]

参加物

4

反応物 1

HCID 543404312-Chlor-5-nitro-benzolsulfonylfluorid

生成物 1

HCID 542778915-Amino-2-chlorobenzene-1-sulfonyl fluoride

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 176Acetic Acid溶媒

実験手順

The 2-chloro-5-nitro benzene sulphonylfluoride (2.4 parts) was stirred. in glacial acetic acid (25 parts) with iron powder (2 parts). Heated to reflux and stirred at reflux for 2.5 hours, then cooled to room temperature, poured onto ice/water and allowed to stand at room temperature overnight. The resultant precipitate was filtered off and dried in air to yield the product 2-chloro-5-amino benzene sulphonylfluoride (0.8 parts).

後処理

  1. temperatureHeated
  2. temperatureto reflux
  3. temperatureat reflux for 2.5 hours
  4. additionpoured onto ice/water
  5. filtrationThe resultant precipitate was filtered off
  6. customdried in air

出典と根拠

ORDレコード
ord-d61bdd17c2804f5a80fda73eca223505
出典データセット
uspto-grants-1998_04
特許番号
US05739299

反応ノート

読み込み中…