HCID 18928128、化合物 → 1-Bromomethyl-2-carboxy-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one

HRID 1599413ノート

反応式

HRID 1599413 の反応式
[Br:1][CH2:2][C:3]1[N:7]2[C:8]3[C:13]([NH:14][C:15](=[O:16])[C:6]2=[N:5][C:4]=1[C:21]([O:23]CC)=[O:22])=[CH:12][C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=3>Br>[Br:1][CH2:2][C:3]1[N:7]2[C:8]3[C:13]([NH:14][C:15](=[O:16])[C:6]2=[N:5][C:4]=1[C:21]([OH:23])=[O:22])=[CH:12][C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=3

参加物

3

反応物 1

HCID 18928128HCID 18928128、化合物

生成物 1

HCID 189281121-Bromomethyl-2-carboxy-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one収率 73%

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

反応条件

温度
80 °C

実験手順

A suspension of 1-bromomethyl-2-ethoxycarbonyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4-(5H)-one (Example 3) (500 mg, 1.2 mmol) in hydrobromic acid (48% in water) (25 ml) was stirred at 80° C. for 16 h. The mixture was concentrated in vacuo, and the residue stirred with water to give 340 mg (73%) of the title compound, which was isolated by filtration. M.p. >250° C.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. stirringthe residue stirred with water

出典と根拠

ORDレコード
ord-dff19a3044164c698ee845ed24987fca
出典データセット
uspto-grants-1998_04
特許番号
US05741785

反応ノート

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