HCID 17877358、化合物 → 2-Carboxy-1-(1-imidazolylmethyl)-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one

HRID 1599415ノート

反応式

HRID 1599415 の反応式
C([O:3][C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][C:25]1[NH:26][CH:27]=[CH:28][N:29]=1)=[O:5])C>Br>[C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:21])([F:20])[F:22])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][C:25]1[NH:29][CH:28]=[CH:27][N:26]=1)([OH:5])=[O:3]

参加物

3

反応物 1

HCID 17877358HCID 17877358、化合物

生成物 1

HCID 178773612-Carboxy-1-(1-imidazolylmethyl)-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one収率 110.2%

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

反応条件

温度
80 °C

実験手順

A suspension of 2-ethoxycarbonyl-1-(1-imidazolylmethyl)-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (Example 5) (1.9 g, 4.69 mmol) in hydrobromic acid (48% in water) (100 ml) was stirred at 80° C. for 16 h. The mixture was concentrated in vacuo, and the residue stirred with methanol to give 1.95 g (88%) of the title compound as a HBr salt, which was isolated by filtration.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. stirringthe residue stirred with methanol

出典と根拠

ORDレコード
ord-6e4560d0154f4217a37a71b46afdfabe
出典データセット
uspto-grants-1998_04
特許番号
US05741785

反応ノート

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