2-Ethoxycarbonyl-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one → 2-Carboxy-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo [1,2-a]quinoxalin-4(5H)-one

HRID 1599417ノート

反応式

HRID 1599417 の反応式
C([O:3][C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][N:25]1[CH:29]=[CH:28][N:27]=[C:26]1[CH3:30])=[O:5])C>Br>[C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:21])([F:20])[F:22])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][N:25]1[CH:29]=[CH:28][N:27]=[C:26]1[CH3:30])([OH:5])=[O:3]

参加物

3

反応物 1

HCID 189281382-Ethoxycarbonyl-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one

生成物 1

HCID 189281222-Carboxy-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo [1,2-a]quinoxalin-4(5H)-one

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

反応条件

温度
80 °C

実験手順

A suspension of 2-ethoxycarbonyl-1-(2-methyl-1-imidazolyl)methyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (Example 7) (300 mg, 0.72 mmol) in hydrobromic acid (48% in water) (20 ml) was stirred at 80° C. for 16 h. The precipitate was collected and washed with ether. M.p. >250° C.

後処理

  1. customThe precipitate was collected
  2. washwashed with ether

出典と根拠

ORDレコード
ord-60f78826e80e43b5b85791ad9afe7c4e
出典データセット
uspto-grants-1998_04
特許番号
US05741785

反応ノート

読み込み中…