HCID 53754201、化合物 → Ethyl 6-amino-1H-benzimidazole-2-acetate

HRID 1599468ノート

反応式

HRID 1599468 の反応式
[N+:1]([C:4]1[CH:18]=[CH:17][C:7]2[N:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:10][C:6]=2[CH:5]=1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:18]=[CH:17][C:7]2[N:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:10][C:6]=2[CH:5]=1

参加物

4

反応物 1

HCID 53754201HCID 53754201、化合物

生成物 1

HCID 54171359Ethyl 6-amino-1H-benzimidazole-2-acetate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of ethyl 5-nitrobenzimidazole-2-acetate (206 mg, 0.83 mmol, 1 equiv.), 10% palladium on carbon (88 mg, 0.08 mmol, 0.1 equiv.), and absolute ethanol (8 mL) was stirred at room temperature under hydrogen (balloon). After 45 minutes, the reaction was filtered through Celite®, and the filtrate was concentrated to afford crude ethyl 5-aminobenzimidazole-2-acetate. This was used without further purification.

後処理

  1. filtrationthe reaction was filtered through Celite®
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-943e802d0a5a4a16a2ed835d1e0a965d
出典データセット
uspto-grants-1998_04
特許番号
US05741804

反応ノート

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