Sodium borohydride → 4,5 Dihydroxymethyl-2,2': 5',2"-terthiophene
反応式
[CH:1]([C:3]1[CH:4]=[C:5]([C:10]2[S:11][C:12]([C:15]3[S:16][CH:17]=[CH:18][CH:19]=3)=[CH:13][CH:14]=2)[S:6][C:7]=1[CH2:8][OH:9])=[O:2].[BH4-].[Na+]>CO>[OH:2][CH2:1][C:3]1[CH:4]=[C:5]([C:10]2[S:11][C:12]([C:15]3[S:16][CH:17]=[CH:18][CH:19]=3)=[CH:13][CH:14]=2)[S:6][C:7]=1[CH2:8][OH:9]参加物
4
実験手順
To a solution of 4-formyl-5-hydroxymethyl-2,2':5', 2"-terthiophene (0.1 g) in methanol (10 ml) was added excess amount of sodium borohydride. The reaction mixture was stirred at room temperature for 40 minutes. Methanol was removed and water was added. The solution was extracted with ethyl acetate, washed with brine, dried over anhydrous magnesium sulfate and concentrated to give brownish solid product (0.1 g), melting point 99°-101° C.