Dimethylformamide → 2,5-Anhydro-6-azido-1,3,6-trideoxy-D-ribo-hexitol

HRID 1600152ノート

反応式

HRID 1600152 の反応式
CC1C=CC(S(O[CH2:12][C@H:13]2[O:18][C@@H:16]([CH3:17])[CH2:15][C@@H:14]2[OH:19])(=O)=O)=CC=1.CN(C)C=O.[N-:25]=[N+:26]=[N-:27].[Na+]>C(OCC)C.O.[Cl-].[Na+]>[N:25]([CH2:12][C@H:13]1[O:18][C@@H:16]([CH3:17])[CH2:15][C@@H:14]1[OH:19])=[N+:26]=[N-:27]

参加物

7

反応物 3

HCID 6228DimethylformamideHCID 33557Sodium AzideHCID 867503552,5-Anhydro-1,3-dideoxy-D-ribo-hexitol 6-(4-Methylbenzenesulfonate)

生成物 1

HCID 867503542,5-Anhydro-6-azido-1,3,6-trideoxy-D-ribo-hexitol収率 77.4%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒HCID 5234Sodium Chloride溶媒

実験手順

A mixture, under argon, of 0.560 g of product from Example 337, 2 ml of N,N-dimethylformamide and 0.250 g of sodium azide is stirred at 75°C. for 12 hours. The reaction mixture is diluted with diethyl ether, washedwith water and saturated sodium chloride, dried and concentrated in vacuo to give 0.238 g of the desired product.

後処理

  1. customdried
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-dfcef002dfb74ef7914735b3e5f97fe5
出典データセット
uspto-grants-1998_04
特許番号
US05744465

反応ノート

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