Benzyl Bromide → 1-Benzyl-3-oxoquinuclidinium bromide
反応式
[CH2:1]([Br:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:9]12[CH2:16][CH2:15][CH:12]([CH2:13][CH2:14]1)[C:11](=[O:17])[CH2:10]2>C(#N)C>[Br-:8].[CH2:1]([N+:9]12[CH2:16][CH2:15][CH:12]([CH2:13][CH2:14]1)[C:11](=[O:17])[CH2:10]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
40.4 g (236 mmol) of benzyl bromide was added dropwise over 15 minutes to 29.5 g (236 mmol) of 3-quinuclidinone in 120 ml of acetonitrile and the suspension formed was filtered through a frit after 2 hours at 25° C. Washing with n-hexane (2×50 ml) and drying gave 65.3 g (93 percent) of 1-benzyl-3-oxoquinuclidinium bromide in the form of a white crystalline solid. Other data concerning the product was: ##EQU4##
後処理
- customthe suspension formed
- filtrationwas filtered through a frit after 2 hours at 25° C
- washWashing with n-hexane (2×50 ml)
- customdrying
出典と根拠
- ORDレコード
- ord-6e2ce608fe1e491aad0dab186bf939a0
- 出典データセット
- uspto-grants-1998_04
- 特許番号
- US05744606
反応ノート
読み込み中…