Water → Ethyl 2-pyridin-3-ylpropanoate
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:2]=1.[Li+].[CH3:14]C([N-]C(C)C)C.O.CCOCC>C1COCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([CH3:14])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:2]=1参加物
6
実験手順
Ethyl 3-pyridylacetate (12.2 g, 73.9 mmol) in THF (30 ml) was added to LDA (81 mmol) in THF (150 ml) over 10 min at -78° C. After 1 h Mel (5.1 ml, 81 mmol) was added to the yellow suspension and the mixture brought to room temperature. H2O (300 ml) and ether (300 ml) was added, the mixture separated, and the organic layer washed with H2O and brine, dried and evaporated to give ethyl 2-(3-pyridyl)propanoate (8.3 g) as a yellow oil.
後処理
- additionAfter 1 h Mel (5.1 ml, 81 mmol) was added to the yellow suspension
- custombrought to room temperature
- customthe mixture separated
- washthe organic layer washed with H2O and brine
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-e1e67158406e495f8ce377dc45162e4c
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05977116
反応ノート
読み込み中…