Methyl 3-(4-hydroxyphenyl)benzoate → 4-(3-Hydroxymethylphenyl)phenol

HRID 1600945ノート

反応式

HRID 1600945 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].C[O:8][C:9]([C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1)=O>O1CCCC1>[OH:8][CH2:9][C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 2

HCID 5097337Methyl 3-(4-hydroxyphenyl)benzoateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 218306904-(3-Hydroxymethylphenyl)phenol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

A solution of lithium aluminium hydride (1 M in ether, 2.5 ml) was added to dry tetrahydrofuran (10 ml) and the solution cooled to 0° C. A solution of 3'-methoxycarbonylbiphenyl-4-ol in (0.57 g) in tetrahydrofuran (10 ml) was then added and the resulting solution stirred at room temperature for 30 minutes. The reaction was then quenched by the addition of water (0.1 ml) followed by aqueous sodium hydroxide (50%, 0.1 ml) and then water (0.5 ml). The mixture was acidified with dilute aqueous hydrochloric acid (2 M) and extracted with ethyl acetate. The organic extract was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the sub-title compound as a white solid (0.48 g).

後処理

  1. customThe reaction was then quenched by the addition of water (0.1 ml)
  2. extractionextracted with ethyl acetate
  3. extractionThe organic extract
  4. dry with materialwas dried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-4b184d30990c42269ec39029db9c71cc
出典データセット
uspto-grants-1999_11
特許番号
US05977105

反応ノート

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