Sodium Hydroxide → (+/-)-1-(2,6-Dimethylbiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

HRID 1600963ノート

反応式

HRID 1600963 の反応式
Cl[CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.[CH3:13][C:14]1[CH:19]=[C:18]([OH:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[OH-].[Na+]>C(O)C>[CH3:21][C:16]1[CH:17]=[C:18]([O:20][CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]2[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:19]=[C:14]([CH3:13])[C:15]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 218306382,6-Dimethylbiphenyl-4-olHCID 22465338HCID 22465338、化合物

生成物 1

HCID 21830751(+/-)-1-(2,6-Dimethylbiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol収率 55%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Prepared according to the method described in Example 24b) from (±)-α-(chloromethyl)-3-pyridinepropanol (0.70 g), 2,6-dimethylbiphenyl-4-ol (0.79 g), ethanol (15 ml) and aqueous sodium hydroxide (1.9 M, 2.5 ml). After work up the residue was purified by column chromatography over silica with ethyl acetate to give the title compound as a solid (0.72 g).

後処理

  1. customPrepared
  2. customAfter work up the residue was purified by column chromatography over silica with ethyl acetate

出典と根拠

ORDレコード
ord-b8a79e300d224738aa69a44045bc9ae2
出典データセット
uspto-grants-1999_11
特許番号
US05977105

反応ノート

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