Ethanol → (2R)-1-(3'-Carboxybiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

HRID 1600966ノート

反応式

HRID 1600966 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]([OH:26])[CH2:18][CH2:19][C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:11][CH:10]=2)[CH:6]=CC=1)#N.[OH-:27].[Na+].[CH2:29]([OH:31])[CH3:30]>O>[C:29]([C:30]1[CH:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]([OH:26])[CH2:18][CH2:19][C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:11][CH:10]=2)[CH:4]=[CH:3][CH:1]=1)([OH:27])=[O:31]

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 54167436(2R)-1-(3'-cyanobiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

生成物 1

HCID 54073875(2R)-1-(3'-Carboxybiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A stirred solution of (2R)-1-(3'-cyanobiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol (0.60 g) and sodium hydroxide (0.696 g) in ethanol (8 ml) and water (2 ml) was heated at reflux for 10 hours. The mixture was concentrated and the residues dissolved in water and neutralised. The precipitate was filtered off and dried under vacuum to give the title compound as a white solid (0.616 g).

後処理

  1. temperatureat reflux for 10 hours
  2. concentrationThe mixture was concentrated
  3. dissolutionthe residues dissolved in water
  4. filtrationThe precipitate was filtered off
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-d935582cdc1f4a4c962f7951b2a6484b
出典データセット
uspto-grants-1999_11
特許番号
US05977105

反応ノート

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