Sodium Hydroxide → 2,5-Dimethyl-3-furoic acid
反応式
[CH3:1][C:2]1[O:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([O:9]CC)=[O:8].[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[O:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([OH:9])=[O:8]参加物
4
実験手順
A mixture of 3.2 g of ethyl 2,5-dimethylfuran-3-carboxylate, 35 ml of ethanol and 20 ml of 2 N sodium hydroxide was stirred at room temperature for 1.5 hours followed by heating under ref lux for an hour. After the reaction mixture was allowed to cool to room temperature, it was concentrated under reduced pressure. The residue was dissolved in water and acidified with diluted sulfuric acid. Precipitated crystals were collected by filtration, washed with water and dried to give 2.27 g of 2,5-dimethylfuran-3-carboxylic acid in a 85% yield.
後処理
- temperatureby heating under ref lux for an hour
- temperatureto cool to room temperature
- concentrationit was concentrated under reduced pressure
- dissolutionThe residue was dissolved in water
- customPrecipitated crystals
- filtrationwere collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-0b79ee921d4c4a5da4958c25b9be5b52
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05977168
反応ノート
読み込み中…