Hydroxyamine hydrochloride → Methyl 2-methoxy-5-formylbenzoate oxime

HRID 1601439

反応式

HRID 1601439 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([CH:13]=[O:14])=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=O.Cl.[NH2:16][OH:17].C([O-])(=O)C.[Na+]>C(O)C.O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([CH:13]=[O:14])=[CH:9][C:4]=1[C:5](=[N:16][OH:17])[O:7][CH3:8]

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 10856352Methyl 5-formyl-2-methoxybenzoate

生成物 1

HCID 86583897Methyl 2-methoxy-5-formylbenzoate oxime

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

反応条件

温度
50 °C

実験手順

Combine methyl 2-methoxy-5-formylbenzoate (5.0 g, 25.9 mmol), hydroxylamine hydrochloride (8.55 g, 133 mmol), and sodium acetate (10.25 g, 125 mmol) in ethanol/water (200 mL, 1/1). Heat to 50° C. After 1 hour, pour the reaction mixture onto ice to give a solid. Collect the solid by filtration to give methyl 2-methoxy-5-formylbenzoate oxime: Rf =0.76 (silica gel, 9/1 dichloromethane/methanol).

後処理

  1. additionpour the reaction mixture onto ice
  2. customto give a solid
  3. customCollect the solid
  4. filtrationby filtration

出典と根拠

ORDレコード
ord-b3842bb5e69f48e5ac375187866c6f23
出典データセット
uspto-grants-1999_11
特許番号
US05977139

関連ノート

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