Lithium Hydroxide → HCID 178489168、化合物

HRID 1601442ノート

反応式

HRID 1601442 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:17][N:16]=[N:15][N:14]=2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Li+].O1CCCC1.O>Cl.ClCCl>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:14][N:15]=[N:16][N:17]=2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

参加物

6

反応物 3

HCID 3939Lithium HydroxideHCID 21881883Oxolane--water (1/1)HCID 178497409HCID 178497409、化合物

生成物 1

HCID 178489168HCID 178489168、化合物

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

Combine methyl 2-methoxy-5-(1H-tetrazol-5-yl)benzoate (1 mmol) and lithium hydroxide (1.1 mmol) in 1/1 tetrahydrofuran/water (5 mL). After 24 hours, dilute the reaction mixture with a 0.5M aqueous hydrochloric acid solution and dichloromethane. Separate the layers and extract the aqueous layer three times with dichloromethane. Combine the organic layers, dry over MgSO4, filter, and evaporate in vacuo to give 2-methoxy-5-(1H-tetrazol-5-yl)benzoic acid.

後処理

  1. customSeparate the layers
  2. extractionextract the aqueous layer three times with dichloromethane
  3. dry with materialdry over MgSO4
  4. filtrationfilter
  5. customevaporate in vacuo

出典と根拠

ORDレコード
ord-d5261fbe54fb487eb84e69f11befb6f8
出典データセット
uspto-grants-1999_11
特許番号
US05977139

反応ノート

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