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Ethanol → 5-{4-[2-(3-Methylimidazo[5,4-b]pyridin-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

HRID 1601788
ノート
印刷プレビュー

反応式

HRID 1601788 の反応式
[NH2:1][C:2]1[C:3]([NH:8][CH3:9])=[N:4][CH:5]=[CH:6][CH:7]=1.O=[CH:11][CH2:12][CH2:13][O:14][C:15]1[CH:28]=[CH:27][C:18]([CH2:19][CH:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:17][CH:16]=1.C(O)C.II>COCCOC.C(O)(=O)C>[CH3:9][N:8]1[C:3]2=[N:4][CH:5]=[CH:6][CH:7]=[C:2]2[N:1]=[C:11]1[CH2:12][CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][CH:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:27][CH:28]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 702EthanolHCID 807IodineHCID 104929285-[4-(3-Oxopropoxy)benzyl]thiazolidine-2,4-dioneHCID 123436692-N-methylpyridine-2,3-diamine

生成物 1

HCID 105719565-{4-[2-(3-Methylimidazo[5,4-b]pyridin-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione収率 3%

試薬・触媒・溶媒 2

HCID 176
Acetic Acid
溶媒
HCID 80711,2-Dimethoxyethane溶媒

実験手順

A procedure similar to that described in Example 18 was repeated, except that 0.94 g of 3-amino-2-methylaminopyridine (prepared as described in Preparation 105), 2.10 g of 5-[4-(3-oxopropoxy)benzyl]thiazolidine-2,4-dione (prepared as described in Preparation 107), 6 ml of ethanol, 3 ml of acetic acid, 2.32 g of iodine and 30 ml of 1,2-dimethoxyethane were used. After working up the product as described in Example 18, the resulting crude product was purified by column chromatography through silica gel, using ethyl acetate as the eluent, to give 85 mg of the title compound, melting at 96-100° C.

後処理

  1. customthe resulting crude product was purified by column chromatography through silica gel

出典と根拠

ORDレコード
ord-fb3b8004977141cb89a4fc7cadc17141
出典データセット
uspto-grants-1999_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05977365

反応ノート

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