6-Isopropoxy-2-methylamino-3-nitropyridine → 6-Isopropoxy-N2-methylpyridine-2,3-diamine

HRID 1601870ノート

反応式

HRID 1601870 の反応式
[CH:1]([O:4][C:5]1[N:10]=[C:9]([NH:11][CH3:12])[C:8]([N+:13]([O-])=O)=[CH:7][CH:6]=1)([CH3:3])[CH3:2]>CO.[Pd]>[NH2:13][C:8]1[C:9]([NH:11][CH3:12])=[N:10][C:5]([O:4][CH:1]([CH3:2])[CH3:3])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 108461726-Isopropoxy-2-methylamino-3-nitropyridine

生成物 1

HCID 108212696-Isopropoxy-N2-methylpyridine-2,3-diamine収率 97.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A procedure similar to that described in Example 6 was repeated, except that 2.38 g of 6-isopropoxy-2-methylamino-3-nitropyridine (prepared as described in Preparation 100) were hydrogenated in 50 ml of methanol in the presence of 0.50 g of 10% w/w palladium-on-charcoal. After working up the product as described in Example 6, 2.00 g of the title compound having Rf=0.62 (on silica gel thin layer chromatography using ethyl acetate as the developing solvent) were obtained.

出典と根拠

ORDレコード
ord-ff68c0e56b374aea8728bb32bcb089f2
出典データセット
uspto-grants-1999_11
特許番号
US05977365

反応ノート

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