反応式
CO[C:3]1[CH:23]=[CH:22][C:6]([CH2:7][CH:8]2[C:17]3[C:12](=[CH:13][C:14](OC)=[C:15](OC)[CH:16]=3)CCN2)=C[CH:4]=1.C([BH3-])#N.[Na+]>>[C:17]1([C:8]([C:7]2[CH:4]=[CH:3][CH:23]=[CH:22][CH:6]=2)([CH2:7][CH2:6][CH3:22])[CH2:4][CH2:3][CH3:23])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
実験手順
The 1,2,3,4-tetrahydro-1-(4-methoxybenzyl)-6,7-dimethoxyisoquinoline was reacted with 7-[N-3-(4-fluorophenyl)propionyl]amino-4,4-diphenylheptanal in the presence of sodium cyanoborohydride as described in example 1 to give 7-[N-3-(4-fluorophenyl)propionyl]amino- I1-N-[ 1,2,3,4-tetrahydro-1-(4-methoxybenzyl)] -6,7-dimethoxyisoquinolinyl]-4,4-diphenylheptane as a film: MS showed (M+H)+ @ 729; 1H-NMR (CDCl3, δ): 1.0-1.22 (m, 4H), 1.91-2.10 (m, 4H), 2.3-2.4 (m, 2H), 2.4-2.85 (m, 6H), 2.85-2.94 (t, 2H), 2.94-3.2 (m, 4H). 3.51-3.67 (m, 1H), 3.55 (s, 31H). 3.76 (s, 3H), 3.82 (s, 3H), 1H. (broad s, 5.13), 5.92 (s, 1H), 6.52 (s, 1H), 6.75-6.97 (m, 6H), 7.07-7.30 (m, 12H); IR (MIC) u 3300, 2950. 1650, 1510 cm-1. The hydrochloride salt was prepared as in example 4 to give 7-[N-3-(4-fluorophenyl)propionyl]-1-[N-(l.2,3,4-tetra- hydro-1-(4-methoxybenzyl)-6,7-dimethoxyisoquinolinyl)]-4,4-diphenylheptane hydrochloride: mp 100-108° C.
出典と根拠
- ORDレコード
- ord-5623d9ba30c34f8faec3efd188a2b8ff
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05981521
関連ノート
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