Trifluoroacetic acid → 4-Amino-6-chloropyrimidine-2-thiol
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9]CC2C=CC(OC)=CC=2)[N:3]=1.FC(F)(F)C(O)=O>>[CH:7]1[C:2]([NH2:1])=[N:3][C:4](=[S:9])[NH:5][C:6]=1[Cl:8]参加物
3
実験手順
4-amino-6-chloro-2-(4-methoxyphenylmethylthio)-pyrimidine (11.0 g, 39.15 mmol: Cpd #93) and trifluoroacetic acid (84 ml) are heated to reflux for 20 hours, then the excess solvent is removed in vacuo. The sample is triturated with chloroform then stirred with ether and filtered. The solid is washed with ether then air dried, mp >320° C.
後処理
- temperatureto reflux for 20 hours
- customthe excess solvent is removed in vacuo
- customThe sample is triturated with chloroform
- filtrationfiltered
- washThe solid is washed with ether
- customair dried
出典と根拠
- ORDレコード
- ord-c2af67178c6f4d18ae6b0358f21c0323
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05981537
反応ノート
読み込み中…