N-bromobutanimide → HCID 19611696、化合物

HRID 1602379ノート

反応式

HRID 1602379 の反応式
[Cl:1][C:2]1[C:10]2[O:9][CH:8]=[CH:7][C:6]=2[C:5]([CH3:11])=[CH:4][CH:3]=1.[Br:12]N1C(=O)CCC1=O>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C(Cl)(Cl)(Cl)Cl>[Br:12][CH2:11][C:5]1[C:6]2[CH:7]=[CH:8][O:9][C:10]=2[C:2]([Cl:1])=[CH:3][CH:4]=1

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 19611698HCID 19611698、化合物

生成物 1

HCID 19611696HCID 19611696、化合物収率 51.6%

試薬・触媒・溶媒 2

HCID 7187Benzoyl Peroxide触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of 7-chloro-4-methyl-benzofuran (CAS-number 79444-976; 51.9 g), N-bromosuccinimide (61.4 g), benzoyl peroxide (0.52 g) and carbon tetrachloride (1200 ml) was heated under reflux under the illumination of an 80 W flood lamp for 20 h. The mixture was cooled, and filtered and the filtrate evaporated to dryness. The residue was absorbed onto silica and purified by chromatography on silica using ethyl acetate and hexane (1:20) to give the title compound (39.50 g) as a yellow solid.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux under the illumination of an 80 W flood lamp for 20 h
  3. temperatureThe mixture was cooled
  4. filtrationfiltered
  5. customthe filtrate evaporated to dryness
  6. customThe residue was absorbed onto silica
  7. custompurified by chromatography on silica

出典と根拠

ORDレコード
ord-9919571e6aea444d8b4e0ad277d78b28
出典データセット
uspto-grants-1999_11
特許番号
US05981572

反応ノート

読み込み中…