(E)-3-(7-Chloro-benzofuran-4-yl)-acrylonitrile → 3-(2,3-Dihydro-benzofuran-4-yl)-propylamine hydrochloride

HRID 1602382ノート

反応式

HRID 1602382 の反応式
[Cl:1][C:2]1[C:10]2[O:9][CH:8]=[CH:7][C:6]=2[C:5](/[CH:11]=[CH:12]/[C:13]#[N:14])=[CH:4][CH:3]=1>C(O)(=O)C.[Pd]>[ClH:1].[O:9]1[C:10]2[CH:2]=[CH:3][CH:4]=[C:5]([CH2:11][CH2:12][CH2:13][NH2:14])[C:6]=2[CH2:7][CH2:8]1

参加物

4

反応物 1

HCID 19611650(E)-3-(7-Chloro-benzofuran-4-yl)-acrylonitrile2 回

生成物 1

HCID 196116703-(2,3-Dihydro-benzofuran-4-yl)-propylamine hydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

A solution of the (E)-3-(7-chloro-benzofuran-4-yl)-acrylonitrile (intermediate 3) (1.0 g) in acetic acid (30 ml) containing 10% palladium on charcoal (50 mg; 50% wet paste) and 5% platinium on charcoal (50 mg) was hydrogenated at 100 psi and 50° for 3 days. The solution was filtered through hyflo and evaporated to dryness and the residue recrystallised from isopropanol to give the title compound as white plates (583 mg).

後処理

  1. filtrationThe solution was filtered through hyflo
  2. customevaporated to dryness
  3. customthe residue recrystallised from isopropanol

出典と根拠

ORDレコード
ord-6f0510d0d41143988681b54c9514f5c0
出典データセット
uspto-grants-1999_11
特許番号
US05981572

反応ノート

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