Ethyl bromoacetate → Ethyl 4-[3-(4-chlorophenylsulfonyl)propyl]-2-[3-[2-(4-phenyl-2-thiazolyl)vinyl]benzoylamino]phenoxyacetate

HRID 1602498ノート

反応式

HRID 1602498 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH2:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([OH:42])=[C:18]([CH:41]=2)[NH:19][C:20](=[O:40])[C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]=[CH:28][C:29]3[S:30][CH:31]=[C:32]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[N:33]=3)[CH:22]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:50][C:51]([O:53][CH2:54][CH3:55])=[O:52]>CN(C)C=O.[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH2:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([O:42][CH2:50][C:51]([O:53][CH2:54][CH3:55])=[O:52])=[C:18]([NH:19][C:20](=[O:40])[C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]=[CH:28][C:29]4[S:30][CH:31]=[C:32]([C:34]5[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=5)[N:33]=4)[CH:22]=3)[CH:41]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 538477505'-[3-(4-Chlorophenylsulfonyl)propyl]-2'-hydroxy-3-[2-(4-phenyl-2-thiazolyl)vinyl]benzanilide

生成物 1

HCID 54512577Ethyl 4-[3-(4-chlorophenylsulfonyl)propyl]-2-[3-[2-(4-phenyl-2-thiazolyl)vinyl]benzoylamino]phenoxyacetate収率 53%

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒HCID 6228Dimethylformamide溶媒

実験手順

5'-[3-(4-Chlorophenylsulfonyl)propyl]-2'-hydroxy-3-[2-(4-phenyl-2-thiazolyl)vinyl]benzanilide (0.60 g, 0.98 mmol) was dissolved in dimethylformamide (6 ml), potassium carbonate (0.20 g, 1.45 mmol), a catalytically effective amount of tetrabutylammonium bromide and ethyl bromoacetate (0.13 ml, 1.17 mmol) were added in that order under ice-cooling, followed by 12 hours of stirring at room temperature. Ice-water was added to the reaction solution and the product formed was extracted twice with benzene-ethyl acetate mixed solution (1:1). The resulting organic layer was washed with 5% potassium carbonate aqueous solution and brine in that order, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent=acetone:chloroform=1:100) and crystallized from acetonitrile to give ethyl 4-[3-(4-chlorophenylsulfonyl)propyl]-2-[3-[2-(4-phenyl-2-thiazolyl)vinyl]benzoylamino]phenoxyacetate (0.36 g, 0.51 mmol, 53%) as colorless crystals.

後処理

  1. temperaturecooling
  2. customthe product formed
  3. extractionwas extracted twice with benzene-ethyl acetate mixed solution (1:1)
  4. washThe resulting organic layer was washed with 5% potassium carbonate aqueous solution and brine in that order
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe resulting residue was purified by silica gel column chromatography (eluent=acetone:chloroform=1:100)
  8. customcrystallized from acetonitrile

出典と根拠

ORDレコード
ord-9baf7bdf12bc443cb319de1cd75238dd
出典データセット
uspto-grants-1999_11
特許番号
US05981559

反応ノート

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