Ammonium Hydroxide → 2-(2-Chloro-4-hydroxyphenyl)acetic acid
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([O:8]C)[CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([OH:13])=[O:12].[OH-].[NH4+]>Br>[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([OH:13])=[O:12]参加物
4
実験手順
A solution of 1.6 g (8 mmol) of (2-chloro-4-methoxyphenyl)acetic acid, prepared according to Preparation 3, in 13 ml of hydrobromic acid (in 48% aqueous solution) is refluxed for two hours. After cooling, ammonium hydroxide is added until the pH is basic, and the mixture is extracted with methylene chloride. The water is evaporated from the aqueous phase and the residue is washed several times with ethanol to give the title compound.
後処理
- temperatureis refluxed for two hours
- temperatureAfter cooling
- extractionthe mixture is extracted with methylene chloride
- customThe water is evaporated from the aqueous phase
- washthe residue is washed several times with ethanol
出典と根拠
- ORDレコード
- ord-aa6990d284b14c799dc46af6932b3928
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05981754
反応ノート
読み込み中…