Hydrochloric Acid → 4-(Acetylamino)-3-hydroxy-5-nitrobenzoic acid

HRID 1602801ノート

反応式

HRID 1602801 の反応式
C([O:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([N+:18]([O-:20])=[O:19])[C:13]=1[NH:14][C:15](=[O:17])[CH3:16])[C:8]([OH:10])=[O:9])(=O)C.Cl>[OH-].[Na+].O>[C:15]([NH:14][C:13]1[C:12]([N+:18]([O-:20])=[O:19])=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]=1[OH:4])(=[O:17])[CH3:16]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 4938463-Acetoxy-4-(Acetylamino)-5-Nitrobenzoic Acid

生成物 1

HCID 33646654-(Acetylamino)-3-hydroxy-5-nitrobenzoic acid収率 98.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

Compound 104 (0.850 g, 3.54 mmol) was dissolved in 0.1N NaOH (80 mL), and the mixture was stirred at room temperature for 4 hours. This was acidified with concentrated HCl (2 mL), diluted with water (20 mL), and extracted with ethyl acetate (3×60 mL). The combined extracts were dried (Na2SO4) and concentrated on a rotary evaporator to give crystalline 105 (0.712 g, 98.4% yield): mp 256-259° C. (methanol).

後処理

  1. extractionextracted with ethyl acetate (3×60 mL)
  2. dry with materialThe combined extracts were dried (Na2SO4)
  3. concentrationconcentrated on a rotary evaporator

出典と根拠

ORDレコード
ord-7c4cca9a79e64a7d9ba801ce8d3baf51
出典データセット
uspto-grants-1999_11
特許番号
US05985859

反応ノート

読み込み中…