Methanol → 4-(4'-Chlorobenzenesulphonyl)biphenyl

HRID 16031

反応式

HRID 16031 の反応式
[C:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1.CO>ClC1C(Cl)=C(Cl)C=CC=1>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([C:4]2[CH:5]=[CH:6][C:1]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)=[CH:2][CH:3]=2)(=[O:22])=[O:21])=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 887MethanolHCID 7095BiphenylHCID 73984-Chlorobenzenesulfonyl chloride

生成物 1

HCID 6300224-(4'-Chlorobenzenesulphonyl)biphenyl収率 65%

試薬・触媒・溶媒 1

HCID 68951,2,3-Trichlorobenzene溶媒

反応条件

温度
110 °C

実験手順

A mixture of biphenyl (10 g, 0.065 mol) and 4-chlorobenzenesulphonyl chloride (13.69 g, 0.065 mol) in trichlorobenzene (3 mL) was heated with stirring to 110° C. Anhydrous ferric chloride (0.05 g, 0.0003 mmol) was added and stirring was continued at 150° C. for 16 h. The cooled solid was stirred with methanol (200 mL). The product was filtered, washed with methanol, dried, and recrystallised from acetic acid to give 4-(4′-chlorobenzenesulphonyl)biphenyl (13.9 g, 65%); m.p. 169° C. (lit. 171-173° C.).

後処理

  1. temperaturewas heated
  2. stirringstirring
  3. filtrationThe product was filtered
  4. washwashed with methanol
  5. customdried
  6. customrecrystallised from acetic acid

出典と根拠

ORDレコード
ord-75e276f8a4ae412098a9bb92b19f2df9
出典データセット
uspto-grants-2010_06
特許番号
US07736539B2

関連ノート

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