Hydrochloric Acid → 3-(Hydroxyaminocarbonyl)methylimidazo[5,1-b]thiazole
反応式
C([O:3][C:4]([CH2:6][C:7]1[N:8]2[CH:14]=[N:13][CH:12]=[C:9]2[S:10][CH:11]=1)=O)C.Cl.[NH2:16][OH:17].[O-]CC.[Na+].Cl>C(O)C>[OH:17][NH:16][C:4]([CH2:6][C:7]1[N:8]2[CH:14]=[N:13][CH:12]=[C:9]2[S:10][CH:11]=1)=[O:3]参加物
6
実験手順
To 2 ml of an ethanol solution containing 204.3 mg of 3-ethoxycarbonylmethylimidazo[5,1-b]thiazole, 108.2 mg of hydroxylamine hydrochloride and 210.2 mg of a sodium ethoxide powder were added, and the mixture was then stirred at room temperature for 2 hours. Under ice-cooling, 0.4 ml of 1N hydrochloric acid was added to the reaction solution to neutralize the solution. The solvent was evaporated under reduced pressure, and the resulting residue was purified by Diaion HP-20 Resin to obtain 140 mg of the title compound.
後処理
- additionwere added
- temperatureUnder ice-cooling
- customThe solvent was evaporated under reduced pressure
- customthe resulting residue was purified by Diaion HP-20 Resin
出典と根拠
- ORDレコード
- ord-e4a0e5b1563f4d25a1527d34a8765996
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05990101
反応ノート
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