HCID 19605759、化合物 → 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethyl-quinazoline

HRID 1603527ノート

反応式

HRID 1603527 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]#[C:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[C:16]2[CH2:23][CH3:24]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][CH2:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[C:16]2[CH2:23][CH3:24]

参加物

4

反応物 1

HCID 19605759HCID 19605759、化合物

生成物 1

HCID 99490646-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethyl-quinazoline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

150 mg of 6-[2-(2,5-dimethoxyphenyl)ethynyl]-4-ethyl-quinazoline are dissolved in 10 ml of ethyl acetate. After addition of 20 mg of palladium (10% on charcoal) the mixture is stirred overnight under an atmosphere of hydrogen and subsequently filtered over celite. The filtrate is evaporated in vacuo and the residue crystallised from cylohexane to obtain the title compound as colourless crystals. mp: 74°.

後処理

  1. filtrationsubsequently filtered over celite
  2. customThe filtrate is evaporated in vacuo
  3. customthe residue crystallised from cylohexane

出典と根拠

ORDレコード
ord-cc9ba045d0294a579aae97e17a56de20
出典データセット
uspto-grants-1999_11
特許番号
US05990116

反応ノート

読み込み中…