Acetic Anhydride → N-(3-bromo-5-nitrophenyl)acetamide

HRID 1603613

反応式

HRID 1603613 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([N+:9]([O-:11])=[O:10])[CH:8]=1)[NH2:5].[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1.O>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][C:12](=[O:14])[CH3:13])[CH:6]=[C:7]([N+:9]([O-:11])=[O:10])[CH:8]=1

参加物

5

反応物 2

HCID 7918Acetic AnhydrideHCID 44535ar-Bromo-ar-nitrobenzenamine

生成物 1

HCID 10658908N-(3-bromo-5-nitrophenyl)acetamide収率 91.5%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1049Pyridine溶媒

実験手順

28.40 g (0.131 mol) of 3-bromo-5-nitroaniline were dissolved in 250 ml of pyridine and treated with 30 ml (0.317 mol) of acetic anhydride. The mixture was stirred at room temperature for 18 hrs. and subsequently at 40° C. for 2 hrs. Then, the residue was digested in water and the precipitate was filtered off. The filter material was rinsed with a large amount of water and dried at 45° C. in a high vacuum. There were obtained 31.0 g (91.5%) of N-(3-bromo-5-nitrophenyl)-acetamide as orange-yellow crystals. MS (ISP): me/e=260, 258 (C8H8BrN2O3+).

後処理

  1. waitand subsequently at 40° C. for 2 hrs
  2. filtrationthe precipitate was filtered off
  3. washThe filter material was rinsed with a large amount of water
  4. customdried at 45° C. in a high vacuum

出典と根拠

ORDレコード
ord-849c30a95b584c4cb3098744679e5144
出典データセット
uspto-grants-1999_11
特許番号
US05990105

関連ノート

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